UNIVERSITY OF IOWA POSTDOCTORAL SCHOLAR in IOWA CITY, Iowa

POSTDOCTORAL SCHOLARRequisition # 2963Position BasicsAdvertising Ends on:Extended Until Position is FilledAdvertising Started on:Wednesday, March 14th, 2018College:Carver College of MedicineDepartment:PediatricsSalarySalary:$47,484.00 to CommensuratePosition DetailsFull/Part Time Status:Full TimePercent Time:100%Position Description:About the Stead Family Department of Pediatrics and UI Stead Family Children's HospitalThe Stead Family Department of Pediatrics is a national leader in pediatric medicine. The Department's mission is to provide outstanding care to the children of Iowa and beyond by being a leader in state-of-the-art clinical care to children, performing cutting-edge research to find new treatments and cures for childhood illnesses, and educating the next generation of pediatric health care providers. The Department comprises the medical and research staff of UI Stead Family Children's Hospital. UI Stead Family Children's Hospital is one of the nation's top-ranked pediatric care and research institutions, and Iowa's only comprehensive children's hospital. A new free-standing Children's Hospital opened in 2017.The Division of Pediatric Allergy, Immunology, and Pulmonary Disease seeks a Post-doctoral Scholar to assist with research efforts on the preclinical development of novel gene therapies for cystic fibrosis. We are broadly interested in host-pathogen interactions, defense mechanisms, and epithelial responses to bacteria and viruses. The lab has a major interest in the pathogenesis and treatment of cystic fibrosis. Additional studies are investigating interactions between airway epithelia and specific viral and bacterial pathogens.The laboratory is performing a variety of gene transfer studies using lentiviral and transposon vectors. We have developed novel lentiviral vector pseudotypes that target receptors on the apical surface of airway epithelia. We are also exploring other nucleic acid based interventions including RNA interference and gene editing for therapeutic purposes. In addition we are investigating genomics approaches such as the connectivity map to identify small molecules to rescue CFTR function. A long-term goal is to develop vector systems with that can be successfully used in children to treat or prevent CF lung disease by gene addition or gene repair.Primary Function:The candidate will assist with research efforts on the preclinical development of novel gene therapies for cystic fibrosis. The candidate will perform experimental studies that interface with international leaders in CF at Children's Hospital of Philadelphia and TaleeBio, a privately held gene therapy company. We seek a candidate with proven ability to work independently and collaboratively to achieve optimized project plans, with the ultimate goal to deliver products that transform the lives of patients.Responsibilities:Conduct research to elucidate the critical molecular and structural components of novel viral pseudotypes that are required to promote and maintain intended gene transfer and gene editing functions of the vector.Conduct molecular biological research to optimize vector biology and enhance genome packaging efficiency and optimize titer for viral vectors.Conduct molecular biological research on novel pseudotypes to enhance the efficiency of target cell transduction and perform studies of functional expression of therapeutic transgenes.Conduct in vitro and in vivo assays.Serve as liaison with process/analytical development and manufacturing group in order to guide the maintenance of vector product quality across multiple production and purification operations and scales.Generate, manage, evaluate, and maintain critical data in a highly organized manner. Author technical reports, method transfer documents, and prepare scientific presentations as needed.Provide project leadership to ensure that internal research objectives and activities are aligned with corporate goals. Drive vector biology research activities wi